U.S. doctors online nowAsk doctors free
United Kingdom
A 25-year-old female asked:

If ibuprofen is a bit unsafe to take with sertraline, what other painkiller can i take? will paracetamol be ok?

1 doctor answer2 doctors weighed in
Dr. Shawn Dalton-bethea
Pain Management 22 years experience
Sertraline interact: Sertraline (Zoloft) and ibuprofen interaction is bleeding. More of a concern for patient with kidney +/- liver issues +/- elderly. Otherwise infrequent ibuprofen in low doses staggered with sertraline will keep down risk to you. Stay below 2400mg/day of ibuprofen. Paracetmaol (Tylenol (acetaminophen)) is fine to take with sertraline. Stay below 3000mg/day of Tylenol (acetaminophen).
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Dec 5, 2017


Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.