Is any real benefit to taking glucosamine?

I do: There have been numerous studies examining this subject. While not every study is favorable there are several well controlled studies which have shown benefit, especially for oa of the knees. Take at least 1, 500 mg daily for at least a 3 month trial before deciding if it helps.

Rebuild cartilage.: The combination of glucosamine and chondroitin has been shown in studies to (1) provide a degree of pain relief in the short term, and (2) trigger growth of new cartilage when taken for at least two years straight. So it can help you pain and reverse some of the chronic damage. You can find this in the health food store. MSM is not necessary and adds to the cost of the product.