Occasionally used: In non small cell cancers of the lung, methotrexate has been employed along with platinum, taxol, (paclitaxel) and other chemo agents. Best for response are in combinations such as carboplat/taxol. In squamous cell Ca methotrexate with citrovorum rescue is somewhat more effective, in destroying the cell mitochondria. In squamous Ca of lung and other sites high dose MTX + rescue can be very effective.
Answered 11/27/2017
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