A member asked:

I take sertraline (zoloft) for depression and got sick. would it be safe to take benadryl (diphenhydramine) while taking my sertraline?

A doctor has provided 1 answer
Dr. Edward Kuhnley answered

Specializes in Child Psychiatry

OK but Caution: Benadryl (diphenhydramine) together with sertraline may increase side effects such as dizziness, drowsiness, & difficulty concentrating. Some people may also experience some impairment in thinking & judgment. You should avoid/limit use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Max Benadryl (diphenhydramine) dose is 300mg/d.

Answered 3/25/2016

5.2k views

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