A member asked:

Can i take benadryl (diphenhydramine) and sudafed while taking wellbutrin?

6 doctors weighed in across 2 answers
Dr. Sophie Duriez answered

Specializes in Psychiatry

No : All these medications are known to raise blood pressure. Check with your primary care physician what is the best treatment for you. Avoid self-medicating! Good luck and keep your health the best way possible

Answered 5/8/2016

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Dr. Georgia Latham answered

Specializes in Family Medicine

Not sudafed: It is okay to take benadryl (diphenhydramine) while taking Wellbutrin, although a less sedating anti-histamine such as Claritin or Zyrtec might be a better choice. Sudafed can result in increased heart rate and/or blood pressure, and these effects may be worsened while taking Wellbutrin. Try taking guafenesin in the form of Robitussin or Mucinex, it is very safe and may be very helpful for your congestion.

Answered 11/28/2017

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