Very different: They're very different: AS generally causes lumbo-sacral pain (that's low back) whereas costochondritis causes pain the costo-chondral junctions which are located in front, upper chest, 2 inches to the left and right of the sternum (breastbone). These are sore to compression in CC. AS is often assoc with a + blood test (for HLA-B27). CC has no blood test. Both improve with NSAIDs like ibuprofen.
Answered 4/10/2015
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