A member asked:

My doc gave me paxil and abilify (aripiprazole) , then the pharmacist said there is a major interaction and to not take them together. i see alot of ppl take these.

9 doctors weighed in across 3 answers
Dr. Johanna Fricke answered

Specializes in Pediatrics - Developmental and Behavioral

A low dose, 2-5 mg: daily,is usually okay. Your psychiatrist will monitor the effects of the aripiprazole, low doses of which are added for depression if symptoms are not controlled by SSRI's. Coadministration of paroxetine, fluoxetine or cinacalcet, inhibitors of the liver enzyme CYP450 2D6 may ^ the plasma concentrations of aripiprazole, which is partially metabolized by the same enzyme. Check with your doctor.

Answered 3/20/2015

3.1k views

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Dr. Lynne Weixel answered

Specializes in Clinical Psychology

Needs to be watched!: The pharmacist is actually right to warn of serious possible interactions. They may not happen often, but you need to watch carefully and contact Dr ASAP if you feel drowsy, faint, have any muscle jerks, twitches, low BP, etc. Get the list from them to know what to do. It's important! Glad you asked - be safe!

Answered 10/15/2017

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Lots of experts: Would have your doctor talk with the pharmacist. I think direct confrontation can help clarify issues. In my opinion, if a pharmacist has a problem with a doctor's prescription, a phone call should ensue to the doctor, not provide confusing advice to the patient.

Answered 10/24/2017

1.3k views

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