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A member asked:
How is the hla gene related to disease?
A doctor has provided 1 answer
Immune regulation: HLA genes regulate the immune system and many diseases, especially auto-immune disorders are linked to certain HLA types. HLA B 27 has a strong link to ankylosing spondylitis. Other HLA linked disorders are diabetes, celiac disease, and rheumatoid arthritis. For a list of other HLA linked disorders, please consult this site: http://www.hladiseaseassociations.com/
Answered 10/28/2015
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Related Questions
A member asked:
If both parents are HLA-B27+ would that guarantee all offspring to have the gene? If so would only 1 positive parent make it a 50% chance?
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Blood tests negative for celiac, hla gene positive, biopsy positive. Could there be another cause for mucosal flattening?
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Why do I have widespread OA at age 36? Mom has aggressive OA/spinal issues. I do not have HLA-B27 gene. Will I be like mom? Have cerv. spondylosis too
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Dr suspects AS; I have the HLA gene and nearly all SpA features. I had a normal lumbar MRI 3 years ago, does this rule out spondyloarthropathy?
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Is the test for HLA-B27 gene a simple YES/NO? Remember my rheumatologist saying "highly elevated". Perhaps inflammation markers or referring to gene?
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