HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

How is the hla gene related to disease?

A doctor has provided 1 answer

Immune regulation: HLA genes regulate the immune system and many diseases, especially auto-immune disorders are linked to certain HLA types. HLA B 27 has a strong link to ankylosing spondylitis. Other HLA linked disorders are diabetes, celiac disease, and rheumatoid arthritis. For a list of other HLA linked disorders, please consult this site: http://www.hladiseaseassociations.com/

Dr Machanic agreed

Answered 10/28/2015

2.1k views

Thank

Related Questions

A member asked:

If both parents are HLA-B27+ would that guarantee all offspring to have the gene? If so would only 1 positive parent make it a 50% chance?

A doctor has provided 1 answer

A member asked:

Blood tests negative for celiac, hla gene positive, biopsy positive. Could there be another cause for mucosal flattening?

4 doctors weighed in across 2 answers

A member asked:

Why do I have widespread OA at age 36? Mom has aggressive OA/spinal issues. I do not have HLA-B27 gene. Will I be like mom? Have cerv. spondylosis too

A doctor has provided 1 answer

A member asked:

Dr suspects AS; I have the HLA gene and nearly all SpA features. I had a normal lumbar MRI 3 years ago, does this rule out spondyloarthropathy?

A doctor has provided 1 answer

A member asked:

Is the test for HLA-B27 gene a simple YES/NO? Remember my rheumatologist saying "highly elevated". Perhaps inflammation markers or referring to gene?

4 doctors weighed in across 3 answers

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

Why do some people develop autoimmune diseases/disorders after viral exposures, while some people do not? Could hla gene mutations be responsible?
Family has Ankylosing Spondylitis(AS) gene, HLA-B27 that comes from dad. Currently mine is inactive. But there is a medicine that could potentially trigger autoimmune disease which I was explained was AS, could mine get triggered by this med if taken?
Can mutations in hla genes cause people to be predisposed to possibly developing an autoimmune condition?
Why would my doctor be testing my hla-b27 gene?
Can htlv-1 virus cause mutations to hla genes (mutations that you did not have from birth)?

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.