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A member asked:
Blood tests negative for celiac, hla gene positive, biopsy positive. could there be another cause for mucosal flattening?
4 doctors weighed in across 2 answers
Unlikely: The blood test is of secondary importance. It depends on what test you had, for instance the immunoglobulin a antibody to tissue transglutaminase may be negative if one already avoids eating gluten. Also, it is not very sensitive. The definitive test is the biopsy (not the gene, which does only show the likelihood of developing the disease. You probably have celiac disease.
Answered 6/26/2020
5.5k views
Yes: A common cause is a recent intestinal infection. However if you have symptoms with the right HLA and + biopsy sounds like you should discuss with your GI doctor.
Answered 9/29/2016
3.6k views
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