A member asked:

Is tolerance an issue whilst taking lyrica (pregabalin) ? i'm on 600mg per day.

4 doctors weighed in across 3 answers

No: No it is not. If it does not work at that dose it is time to consider other therapies.

Answered 3/8/2015

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Dr. Charles Turck answered

Specializes in Pharmacology

Not really: If, by 'tolerance,' you mean that your pain is no longer relieved, then you will need to involve the doc who prescribed it. Depending on what you're taking it for and your history of response, the doc may decide to add another drug or replace this one entirely. Either way, know that you are at the highest daily dose and that you should not stop taking it suddenly and without talking to your doc.

Answered 3/12/2015

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Dr. Paul Grin answered

Specializes in Pain Management

Has some tolerance: This means that over time a frequent Lyrica (pregabalin) user may require a higher dosage in order to achieve the same effect. You are at the maximum recommended dose is 600 mg per day.

Answered 3/12/2015

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