How long generally does lyrica (pregabalin) start to work ?

Lyrica (pregabalin) 7-10 days: In clinical studies in neuropathic pain some patients experienced a decrease in pain in as early as 7-10 days with a minimum dosage 150 mg BID.

It depends: It depends on achieving a dose that is effective for you. Generally, a low dose is started initially and then the dose is slowly increased until benefit is seen or side effects occur.