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A 26-year-old male asked:

My mom, safia, 60 years old, resident of pakistan has drug induced parkinsonism, which is bothering a lot & worsening. sinemet (carbidopa and levodopa) 25/250 every 4.5 hours?

1 doctor answer2 doctors weighed in
Dr. Dean Giannone
Internal Medicine 25 years experience
Tachyphylaxis.: Dosing of Sinemet (carbidopa and levodopa) is a little strange, requiring front loading in the day and a long gap at night without dosing. If taken like most other medications, on a more regular dosing interval, tachyphylaxis develops, which essentially means the efficacy of the medication reduces.

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Last updated Nov 28, 2017

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