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Silver Spring, MD
A 64-year-old male asked:

What is the difference between parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?

1 doctor answer2 doctors weighed in
Dr. Eric Weisman
Neurology 36 years experience
COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo (carbidopa and levodopa and entacapone) is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa.

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Similar questions

Silver Spring, MD
A 65-year-old male asked:

Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinsons? Is one better than the other?

1 doctor answer1 doctor weighed in
Dr. John Gaffney
Psychiatry 25 years experience
Superiority?: All of the drugs in this class attempt to increase the levels of circulating dopamine. Sinemet is a combination of 2 drugs whereas Stalevo (carbidopa and levodopa and entacapone) is a combination of 3. There is currently an ongoing study at the Mayo Clinic to answer this question - but right now - there isn't any data to demonstrate if one is 'better' than the other. The best treatment is the one that works for you. Hope that helps!
A 38-year-old member asked:

How safe is the parkinson tablet sinemet (carbidopa and levodopa)?

2 doctor answers7 doctors weighed in
Dr. Ahmad M Hadied
Orthopedic Surgery 49 years experience
Ther are side effect: Sinemet (carbidopa and levodopa) average satisfaction score 62% of patients are at least somewhat satisfied with sinemet (carbidopa and levodopa). All medicines may cause side effects, but many people have no, or minor, side effects. Confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; increased sweating; loss of appetite; nausea; taste changes; trouble sleeping; upset stomach; urinary tract infection; vomiting.

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Last updated Oct 7, 2017

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