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A 35-year-old male asked:

Does metformin increase alt (sgpt) level?

2 doctor answers5 doctors weighed in
Dr. Rawhi Omar
Pathology 45 years experience
Rarely: About one in 10000 patients may experience mild liver toxicity (expressed as elevates ALT & AST ).
Dr. Ed Friedlander
Pathology 45 years experience
Best approach: Metformin is often prescribed for conditions in which liver enzymes rise (the non-alcoholic fatty liver family), and when these are present, the enzymes can rise late. I'd only conclude metformin is the cause if hepatitis B & C, Wilson's, alcohol, other meds (ibuproten can do it), autoimmunity are ruled out, liver's not fatty, and withdrawing metformin resolves this.
Last updated Jul 9, 2018

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