What to do for lipoma pain?

Depends...: If is a solitary one and painful and also localized in a place that could interfere with quality of life, it should be removed. If there are however many of them surgery should be reserved to the larger ones. If a rapid grow is observed it should be checked and even biopsied as it can degenerate in a nasty tumor.

Surgical removal : As the lipoma swells it causes more pain. The nerves that supply that area will become more inflammed and continue to cause more pain. Unfortunately you can try other methods like nonsteroidals but not much success. If you can have surgery this may relieve the pain.

Excision: Lipoma is usually left alone until/unless it begins to hurt / bother you due to pressure / etc., on it. Should see surgeon for outpatient (/office) procedure to have it removed.