What are side effects from coming off prednisone ?

Varied: Most people feel tired and may have aches and pains. Often the joints may feel stiif or hurt(arthralgias). Appetite may be diminished too. It is like coming of a pep pill..So there is a run down feeling for a few days before you feel back to normal well being.

Generally minor: But depends upon how long one has been taking them. Biggest problem is usually return of the disease that Prednisone was suppressing. In very rare instances one can have acute adrenal insufficiency manifested by abdominal pain, fever, loss of consciousness, weakness.