What proinflammatory mediator is responsible for hyptension in septic shock?

LPS: Lps, or endotoxin, is classically reported as the culprit for hypotension in septic shock; the body's reaction to it is a profound vasodilation, resulting in the usual distributive shock picture.

Many: Too many to list, there are probably hundreds of mediators that are thought to play some role in septic shock, not just one. A gas called Nitric Oxide made by many different kinds of cells is important in causing the low blood pressure since it causes blood vessels to dilate, but there are multiple other substances involved.