Is it safe to take amoxicillin and xanax (alprazolam) together?

Yes but only if . . : Neither epocrates.Com nor drugs.Com mentioned any interaction btwn Amoxicillin & alprazolam. However, it's best that you address this question to your prescribing doctors & dispensing pharmacists who both need to know everything you're taking whether over-the-counter or prescription before prescribing you anything else in order to avoid these concerns for possible interactions.