Yes but only if . . : Neither epocrates.Com nor drugs.Com mentioned any interaction btwn Amoxicillin & alprazolam. However, it's best that you address this question to your prescribing doctors & dispensing pharmacists who both need to know everything you're taking whether over-the-counter or prescription before prescribing you anything else in order to avoid these concerns for possible interactions.
Answered 9/25/2019
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