What can cause random eye pain in the middle of the night?

Typical symptoms: This is the usual scenario for corneal erosion. This is when this surface layers of the cornea slough off it attachments. People usually are awakened by pain. You need to have your eyes examined to see if you ar at risk of this as the cause of your eye pain at night. One less severe thing that can cause some pain is dryness. Try using some lubricating eye drops at night, refresh or systane.