Any problem with taking medformin hcl 500 (diabetic and high bp) with ic amlodpine besylate 5 mg and lisinopril hctz (hydrochlorothiazide) 20 12.5 mg cut in half in morning?

Should not be.: Commonly used medications, including in that combination.

No problem, but...: Metformin should be taken with meals, and 500 mg is a very low dose. It (immediate release metformin) needs to be taken twice a day to be effective and 2000 mg/d is the most effective dose if tolerated. Amlodipine is ok, but can cause some fluid retention, particularly in people with diabetes. The hctz (hydrochlorothiazide) can raise your blood sugar and increase your lipids. Higher Lisinopril w/o hctz (hydrochlorothiazide) would be better.