Very painful left wrist just art the base of the thumb is where its worst, sometimes spreading around the whole wrist joint and the back of my hand.?

Wrist: Sounds like de Quervain's tenosynovitis. Start with ice and a splint that immobilizes your wrist and thumb. If not improving, see your physician for a cortisone injection.

Other possibilities : Include thumb extensor tendonitis and basal joint arthritis of the thumb. Look these up online. Then see a board certified hand surgeon for a comprehensive evaluation.