A member asked:

Why does it take weeks/months for many depression meds to 'kick in'?

A doctor has provided 1 answer
Dr. Pamela Pappas answered

Specializes in Psychiatry

Great question: Researchers have been asking this question for a long time, because the clinical facts go against the notion that antidepressant effectiveness depends only on serotonin and other neurotransmitter availability changes. Those actually happen long before antidepressant effect "kicks in" -- meaning that antidepressant response could also require neural changes that take longer to develop.

Answered 4/5/2017

5.3k views

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