May lead to cancer: Progression to invasive cancer occurs in approximately 1% of cin1, 5% in cin2 and at least 12% in cin3. Progression to cancer takes 15 (3 to 40) years. Also, evidence suggests that cancer can occur without first detectably progressing through these stages and that a high grade intraepithelial neoplasia can occur without first existing as a lower grade. Eventually this will lead to a cancer.
Answered 3/9/2013
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