Either, not both: Pepto bismol (bismuth subsalicylate), is used to relieve diarrhea, stomach upset, heartburn, stomach acidity, and nausea. Imodium (loperamide), is used in the treatment of diarrhea. There will seldom be a need for both, but there is no significant interaction that should prevent your taking them together, although generally unnecessary.
Answered 11/19/2019
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