A member asked:

My mother and father has no osteogenesis imperfecta but i have.. from whom i inherent this disease?

4 doctors weighed in across 3 answers

From one of them or: Most people will receive from one of the p[arents but in35% of cases it is an individual mutation or sporadic, means it just appers without coming from either parent.

Answered 3/26/2013

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Dr. George Gantsoudes answered

Specializes in Pediatric Orthopedic Surgery

Could be new: The genetic mutation that leads to osteogenesis imperfecta could have been a spontaneous mutation making you the first one to have it in the family.

Answered 7/3/2013

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Depends on type: There are 8 subtypes of OI recognized at this point.Many arise as new mutations and have a dominant mode of inheritance, meaning if your parent didn't have it you got a new mutation. Some subtypes have a recessive mode of inheritance, meaning both parents carried a silent gene they passed to the affected kid.

Answered 11/1/2015

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