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A member asked:
My mother and father has no osteogenesis imperfecta but i have.. from whom i inherent this disease?
4 doctors weighed in across 3 answers
From one of them or: Most people will receive from one of the p[arents but in35% of cases it is an individual mutation or sporadic, means it just appers without coming from either parent.
Answered 3/26/2013
5.3k views
Could be new: The genetic mutation that leads to osteogenesis imperfecta could have been a spontaneous mutation making you the first one to have it in the family.
Answered 7/3/2013
5.3k views
Depends on type: There are 8 subtypes of OI recognized at this point.Many arise as new mutations and have a dominant mode of inheritance, meaning if your parent didn't have it you got a new mutation. Some subtypes have a recessive mode of inheritance, meaning both parents carried a silent gene they passed to the affected kid.
Answered 11/1/2015
2.1k views
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