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A member asked:
Are there more risks or benefits with use of weekly methotrexate as injection vs oral for arthritis or ctds. why is oral usually prescribed?
2 doctors weighed in across 2 answers
Oral is inferior: Oral Methotrexate has more side effects, has variable absorption (only 30-70% compared to 100% injected methotrexate), and causes more nausea. The only reason it is prescribed more in adults is because there are no needles involved (adults will almost always choose pills if given a choice). In kids, we most often don't recommend or offer pills for the reasons listed above. Injections don't hurt.
Answered 6/28/2014
5.3k views
No: There is no increased risk in fact many believe the injectable form is better as it gets directly into bloodstream and does not depend on absorption from the gut.
Answered 12/28/2015
4.7k views
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