A member asked:

Does celecoxib really have a lower risk of gi problems compared to other nsaids?

6 doctors weighed in across 3 answers
Dr. Joram Seggev answered

Specializes in Internal Medicine - Allergy & Immunology

Yes, it does: Several studies and meta-analysis have shown lower incidence of ulcers and blood loss from the GI tract with celxocib than nsaid. That was true in elderly patients as well. In patients who were on Aspirin in addition to celexocib, there was no difference in bleeding from patients on Aspirin and a nsaid.

Answered 6/24/2014

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Yes: Becasue Celebrex (celecoxib) has a preference for blocking an enzyme called cox 2, leaving another enzyme cox1 alone, it is safer on the GI tract. Studies show that there is less GI bleeding and abdominal pain will Celebrex (celecoxib) compared to other nsaids such as Motrin and naproxyn.

Answered 6/30/2014

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Dr. Thomas Namey answered

Specializes in Rheumatology

Yes!: It is cycloxegenase 2 specific. This makes it more tolerable for the gut! Only cox-2 specific drug left on the market in the US!

Answered 11/27/2017

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