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A 46-year-old female asked:

Is nucleolar pattern always diffuse scleroderma?

3 doctor answers3 doctors weighed in
Dr. Michael Fisher
Dermatology 32 years experience
Nucleolar Pattern: There are many different kinds of the nucleolar pattern. It can be speckled, cytoplasmic etc. Knowing what the pattern was is important in trying to figure out what is going on. That being said, if all you know is that it was nucleolar it can mean that you have some sort of "overlap" syndrome, which can include lupus, sjogrens syndrome, crest, scleroderma etc.
Dr. Thomas Namey
Rheumatology 48 years experience
Probably not!: While many with systemic scleroderma do have a "nucleolar" ana, most patients that i see have no manifestations of disease. So, do we know in twenty years what will happen. No. These studies have not been done. A positive ANA without disease manifestations is a "false" positive. Apart from the ANA pattern, 5% of the population has a positive ANA and no connective tissue disease.
Dr. Tracy Lovell
Rheumatology 21 years experience
Not necessarily: False positive anas and false ANA pattern identification can occur.

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Last updated Sep 16, 2019

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