Mixed Picture: It would be very rare (but not impossible) to truly have both diseases together. It would be more likely to develop a so-called "overlap syndrome" in which you have a single autoimmune disorder that seems to borrow some features from each of these classic diseases without truly being purely one or purely the other.
Answered 9/6/2013
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Yes: Scleroderma and lupus are diseases that have different manifestations due to different disease mechanisms, yet they can overlap. Additionally, scleroderma is historically difficult to diagnose early. There are manifestations such as Raynaud's phenomenon that occur in both conditions.
Answered 6/29/2018
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