Is the high liver enzymes from chemo & cancer ( yellow skin, fatigue, weakness) sign of end of life? 3 yrs treated from cancer for 65 years old

Jaundice : A number of things can cause jaundice and elevated liver function tests, including obstruction by neoplasms. Although the prior cancer history is unclear from your question, imaging studies, as well as serum (blood) studies, based on the original cancer, may be very helpful.

Unknown: Yellow skin/jaundice can be from liver obstruction, liver damage, or other causes. If the cancer has spread and liver damage is confirmed this may indicate chemotherapy may no longer be safe. If increasing fatigue, anorexia (low appetite), drowsiness is also seen, that might indirectly indicate that cancer is reaching terminal stage or possibly be side effects of chemotherapy. Check with your md.

Discuss: This could be sign of liver toxicity or another medical condition. You should discuss these symptoms with your treating oncologist.