Is smoking marijuana while on prednisone advisable?

Not recommended. : Assuming you are on Prednisone for respiratory reasons, (asthma or other lung issue), smoking any form of substance introduces noxious particles that will perpetuate the inflammation. Furthermore, the inflammation created by marijuana smoke inflammation is unlikely to be responsive to prednisone. I would not advice any exposure to any inhaled noxious particles.

Prednisone/pot: Some side-effects reported with Prednisone are unusual thoughts or behaviors, sleep disturbances, effect on respiration & heart & blood pressure, blurred vision. Marijuana use can exacerbate the same.