A member asked:

Are triptans contraindicated w/ snri/ssri's?

4 doctors weighed in across 2 answers
Dr. Alan Ali answered

Specializes in Psychiatry

Triptans/SRIs: Triptans are serotonin receptor agonists, hence cause increase serotonin. The ssri/snris are serotonin reuptake inhibitors, hence also raise serotonin. End result, depending on dose & how often used, is possibility of serotonin syndrome. Caution is needed if combination.

Answered 1/5/2013

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Serotonin syndrome : The actual risk of serotonin syndrome remains extremely low when using triptan and antidepressants. As patients with migraines, also have co morbidities like depression, we use this combination often.

Answered 9/29/2016

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Can you do a direct switch from and SSRI to an SNRI?

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