Which medicine is best for gerd? pantaprazole or famotidine?

Apples & oranges: Both medications are acid blockers, but their similarity ends there. Famotidine is an h2-receptor blocker that diminishes acid production, whereas Pantoprazole is a proton pump inhibitor that nearly extinguishes acid output. If you have acid reflux, less acid means better relief--so Pantoprazole would be a better rx choice. No drug is perfect, so discuss pros & cons of each drug with your doctor.