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A member asked:

Currently take amitryptaline 10 mg nightly for migraines is it safe to take nyquil for a cold or will there be an adverse interaction between the two?

4 doctors weighed in across 2 answers

Caution is advised: There is a drug to drug interaction between the 2 agents. The combination may increase the risk of CNS depression, psychomotor impairment, and anticholinergic adverse effects (additive effects). Hence, i would advise against the use of the 2 agents concomitantly.

Dr Machanic and another doctor agreed

Answered 5/16/2016

5.4k views

Thank
Dr. Neetu Ahluwalia answered

Specializes in Pain Management

It should be ok: Start with allow dose of nyquil if your concerned.

Answered 12/28/2012

5.4k views

Thank

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