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A member asked:

Currently take amitryptaline 10 mg nightly for migraines is it safe to take nyquil for a cold or will there be an adverse interaction between the two?

2 doctor answers4 doctors weighed in
Dr. Donald McCarren
Neurology 37 years experience
Caution is advised: There is a drug to drug interaction between the 2 agents. The combination may increase the risk of CNS depression, psychomotor impairment, and anticholinergic adverse effects (additive effects). Hence, i would advise against the use of the 2 agents concomitantly.
Dr. Neetu Ahluwalia
Pain Management 21 years experience
It should be ok: Start with allow dose of nyquil if your concerned.

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Last updated May 16, 2016


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