How long do you need to wait before drinking alcohol after treatment with diflucan (fluconazole)?

Probably 1 wk : Fluconazole (diflucan) interaction with alcohol is probably less severe than other similar medications i.e. Metronidazole. However, Diflucan (fluconazole) is a long acting medicine and stays in your system for approxmtly a week, so it is better to avoid any alcohol (even medicinal) for 7-10 days.

Alcohol/diflucan: Diflucan (fluconazole) can stay in your system 5-7 days since it is long-acting, and although interactions are not severe, it is advised that u not drink alcohol for at least 5 days.