My girlfriend is clinically depressed and currently on zoloft (sertraline). she wants to smoke pot..side efcts?

Whoa. : Weed is definitely associated with an increased risk of schizophrenia and psychotic symptoms. Patients with depression don't need that increased risk. Many depressed patients have anxiety disorder as well. Sometimes smoking makes them chill and feel better. However, in the long run this is dangerous. It's best to have your gf discuss this with her doctor and seek additional proper treatment.

Bad idea: Mixing antidepressant medication with smoking marijuana is a bad idea but unfortunately all to common. The effects are unpredictable and highly individually variable. It may increase depression, render the medication ineffective, cause paranoia, increased mood swings, irritability. Don't join her in smoking pot and encourage her to ask her doctor about it.