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A 18-year-old member asked:

My girlfriend is clinically depressed and currently on zoloft (sertraline). she wants to smoke pot..side efcts?

2 doctor answers6 doctors weighed in
Dr. Carla Enriquez
Pediatrics 50 years experience
Whoa. : Weed is definitely associated with an increased risk of schizophrenia and psychotic symptoms. Patients with depression don't need that increased risk. Many depressed patients have anxiety disorder as well. Sometimes smoking makes them chill and feel better. However, in the long run this is dangerous. It's best to have your gf discuss this with her doctor and seek additional proper treatment.
Dr. Emmett Miller
Psychiatry 54 years experience
this would be risky behavior. There are certainly people who take Zoloft and smoke and get away with it, but there are people who drive at 120 mph and get away with it. Since depression is often a very dangerous illness, leading to withdrawal, suicide, etc. - and since pot can trigger anxiety and depression as side effects, this is not a wise move. thereareother medications that can augment Zoloft
Nov 18, 2011
Dr. Gerald Bausek
Psychiatry 42 years experience
Bad idea: Mixing antidepressant medication with smoking marijuana is a bad idea but unfortunately all to common. The effects are unpredictable and highly individually variable. It may increase depression, render the medication ineffective, cause paranoia, increased mood swings, irritability. Don't join her in smoking pot and encourage her to ask her doctor about it.

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Last updated May 10, 2016

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