How do i prevent prednislone loosing muscle ?

Exercise: The steroid myopathy, weakening of muscle, is related to chemical changes without inflammation. When it feels weak and doesn't move; the muscle will decrease in size and strenght, creating a vicious cycle. Is dose dependent and improves lowering the dose and can be prevented or improved by exercise. It is also unpredictable, some people get it even with low doses.

Weight lifting: Strength training may help decrease muscle loss from steroid medications. Testosterone therapy may be another option if you have low testosterone levels.