I have a persistent pain in leg, thigh and calf. what shouldi do?

Both sides or one: We always are concerned about blood clots if one side. If both sided we can consider vascular, musculoskeletal , arthritis , tendon bursas i would advise you discuss this with your doctor.

Need more info : There are some drugs which can cause this type of pain (statins for cholesterol is common).There are also a number of conditions that may also cause this problem. The best thing to do is get checked.

Many possibilities: Pain could be due to different reasons. A thorough history and physical exam and possibly some laboratory and radiology exams may help to determine the right cause. Pain may be due to: trauma (fracture, sprains, arthritis, ulcers), infection, metabolic conditions (gout), biomechanical abnormality, blood clot, nerve damage (neuropathy) and etc. Get evaluated and get the appropriate care.