What medication is best for arthritis, when you have gerd?

None.: If you have arthritis reducing inflammation is most important. You are referring to nsaids that relieve pain. The drugs that are least likely to exacerbate gerd are Celebrex (celecoxib) and meloxicam. Acetominophen will not cause problems but is less effective. Also, pro-drugs, inactive in the stomach, but converted to the active drug by the liver work well: Nabumetone , an example. Salsalate works well.