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A female asked:

how long/how many days does it take for 0.25 mg doses of xanax (alprazolam) to start taking affect and make one feel relaxed, calm, and less anxious?

2 doctor answers3 doctors weighed in
Dr. Vanja Kondev
Psychiatry 17 years experience
Xanax (alprazolam): Xanax (alprazolam) is a short acting sedative. The calming effect should be immediate.
Dr. Imad Khreim
Dr. Imad Khreim commented
Psychiatry 39 years experience
Short acting Benzo's are effective in relieving anxiety almost immediately, however , due to their short half life they tend to have inter-dose withdrawal and consequently elevating the baseline anxiety and making things worse on the long ru.
Dec 2, 2012
Dr. Bahman Omrani
Pain Management 17 years experience
Xanax (alprazolam) not working : The benzodiazepine (e.g. Xanax) naive patient should feel the effect within the hour. Individuals are unique and depending on one's pharmacogenetics/liver metabolism of medications, the medication may work for some but as well for others. The prescribing physician should be informed. More importantly, non-medicinal modalities & non-habit forming medications should be attempted first.

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Last updated Mar 19, 2016

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