Can you overdose from heroin while taking naltrexone ?

Well...be careful.: Yes. Naltrexone blocks opioid receptors, so it's a good option for people who are detoxed already. If Naltrexone is used prior to detox, it will lead to immediate withdrawal symptoms. In addition, use of opioids after discontinuing Naltrexone are at risk for serious overdose, most likely due to loss of tolerance. Naltrexone is best for motivated people who have already undergone detoxification.

Yes: It is sad, but yes.... People do heroin while on Naltrexone and do not feel any effects. Then they do more and more and more.... Eventually and suddenly, the load of heroin overcomes the receptor blockade and overdose happens. Do not do heroin while on naltrexone.