A member asked:

Will narcan (naloxone) reverse an opiate overdose once cardiac arrest has occurred?

10 doctors weighed in across 6 answers
Dr. Joseph De Santi answered

Specializes in Family Medicine

Arresting Narcan (naloxone): It depends entirely on the method of delivery and the interval circulation during the arrest. The medication will certainly do its pharmacologic action as long as circulation is restored to some extent. The onset of action may be delayed but the drug efficacy should be unaffected once administered. As with all drugs administered during an arrest their efficacy is diminished to some extent.

Answered 7/5/2012

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Dr. Michael Depietro answered

Specializes in Pulmonary Critical Care

Not completely: Narcan (naloxone) can reverse a narcotic overdose to a point. If someone takes a narcotic overdose, and it is enough to stop breathing, the lack of oxygen and rise in carbon dioxide can cause the heart to stop ( cardiac arrest) at that point simply reversing the effect of the narcotic that started the process is not enough, one take additional measures to restore a pulse and resuscitate the patient.

Answered 11/16/2018

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Dr. Heidi Fowler answered

Specializes in Psychiatry

Once there is a : cardiac arrest other life-saving measures must be instituted. “There is no good evidence to suggest that naloxone improves outcome in patients with opioid-induced cardiac arrest. Thus, once arrest has occurred, airway control is a priority before administration of naloxone. ” REF: https://www.pdr.net/drug-summary/Narcan-naloxone-hydrochloride-3837

Answered 11/16/2018

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Dr. William Walsh answered

Specializes in Addiction Medicine

Well....: Narcan (naloxone) will reverse the opiate effect if it is circulated by chest compressions; however, if you have a cardiac arrest from an opiate overdose it is likely that you've already suffered a significant brain injury and you may not survive the arrest.

Answered 6/30/2014

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Not likely: Once cardiac arrest has occurred there is no circulation to carry medications especially if CPR is not being done. Furthermore, Narcan (naloxone) will do nothing to reverse an arrest.

Answered 2/5/2017

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Probably not: Narcan (naloxone) will reverse respiratory arrest. This means that if a person has stopped breathing due to an overdose of Oxycontin or heroin, for example, Narcan (naloxone) can bring back the drive to breathe. If the person doesn't breathe for a long time, though, the heart will stop, which is called cardiac arrest, due to lack of oxygen. Narcan (naloxone) won't fix that. This is why narcotic abuse is so dangerous.

Answered 11/22/2019

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