A 40-year-old member asked:
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how long does it take naloxone to get out of my system?

2 doctor answers
Dr. Joseph De Santi
28 years experience Family Medicine
Nifty Naloxone: Naloxone, or Narcan (naloxone) is intended to reverse narcotic overdose and is usually given in the vein, muscle or breathing tube (in emergencies). It has a very rapid onset of action but a short life in the body. It's half life is 64 minutes, which means in approximately 4 hours it is completely out of the body primarily through the kidneys. Diminished kidney function could prolong the drug effect.
Answered on Jun 1, 2019
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Dr. Arthur Heller
42 years experience Gastroenterology
The drugs it reverses may have a longer half life than the naloxone, so it is possible to wake up, then zonk out again after the effects of naloxone wear off
Dec 31, 2011
Dr. Alan Wartenberg
A Verified Doctor answered
A US doctor answered Learn more
20-30 minutes: Naloxone is short acting. When given intravenously, it lasts 20-30 minutes; if it is given by nasal spray, takes a little longer to kick in (minutes instead of seconds) but lasts a little longer, perhaps up to an hour. Since many opiates are longer acting than that (esp Methadone and oxycontin), an od can recur after the Naloxone wears off. Naloxone is not tested for in most drug testing.
Answered on Jul 10, 2018
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