U.S. doctors online nowAsk doctors free
A 31-year-old member asked:

does naloxone block the body's placebo pain-lowering response?

3 doctor answers5 doctors weighed in
Dr. Barbara A Majeroni
Specializes in Family Medicine
No: Naloxone blocks the response to opioid drugs. A placebo response would not be affected.
Dr. Alan Wartenberg
A Verified Doctoranswered
A US doctor answeredLearn more
Unknown: Since some large part of the "placebo" response is the bodies' own release of endorphin, it makes sense to think that the use of a blocking agent might interfere with that. Naloxone is very short-acting and is usually used intravenously (and sometimes thru nasal spray), but Naltrexone (and nalmefine) are oral drugs that last much longer. None of my patients on this have complained of pain.
Dr. Lewis Margolis
Anesthesiology 48 years experience
Narcotic antsgonists: Naloxone is capable of blocking placebo response since both pain relievers such as morphine and endorphins from placebo both work on mu pain receptors. Naloxone is short acting, and usually administered I.V. And/or i.M. Naltrexone is an oral antagonist which works by a different mechanism.

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
$30 per visit with
membership

Related questions

A 24-year-old member asked:
2 doctor answers6 doctors weighed in
A 38-year-old member asked:
2 doctor answers5 doctors weighed in
A 40-year-old member asked:
1 doctor answer1 doctor weighed in
A 29-year-old female asked:
2 doctor answers7 doctors weighed in
A female asked:
1 doctor answer1 doctor weighed in

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
$30 per visit with
membership
Last updated Nov 27, 2017

People also asked

Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
$30 per visit with
membership

Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.