A 31-year-old member asked:
does naloxone block the body's placebo pain-lowering response?
3 doctor answers • 5 doctors weighed in
Specializes in Family Medicine
No: Naloxone blocks the response to opioid drugs. A placebo response would not be affected.
6.3k viewsAnswered >2 years ago
A Verified Doctoranswered
Unknown: Since some large part of the "placebo" response is the bodies' own release of endorphin, it makes sense to think that the use of a blocking agent might interfere with that. Naloxone is very short-acting and is usually used intravenously (and sometimes thru nasal spray), but Naltrexone (and nalmefine) are oral drugs that last much longer. None of my patients on this have complained of pain.
5.4k viewsAnswered >2 years ago
Anesthesiology 48 years experience
5k viewsReviewed >2 years ago
Last updated Nov 27, 2017
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