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A member asked:

What med is better for you actos (pioglitazone) or glyburide i am a 65 year old man whom have been taken glyburide and now my dr want's me to take actos (pioglitazone) i have notice that actos (pioglitazone) have been haveing a lot of lawsuirs

2 doctor answers2 doctors weighed in
Dr. Daniel Weiss
Endocrinology 46 years experience
There : There are pros and cons to all meds. Glyburide is a frequent cause of low blood sugar, sometimes life threatening. It tends to cause weight gain also. As a diabetes specialist, i never prescribe glyburide. Actos (pioglitazone) has many benefits despite the lawsuits. Metformin is often stopped when people can still stay on it. The slow release form of metformin is better tolerated from a diarrhea/stomach standpoint. Metformin is very cheap or even free in some areas of the country.There are newer excellent agents that do not cause low sugar and some can be helpful for weight loss. Insulin is sometimes the best approach and if used right, safer than glyburide. See the links below.
Dr. Afshine Emrani
Cardiology 28 years experience
In : In your age group, i prefer glyburide, but there are many issues to be addressed. Actos (pioglitazone) has many side effects such as swelling of the legs and weight gain and should not be taken if you have active congestive heart failure or coronary artery disease.

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Last updated Oct 4, 2016

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