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Taking trazodone with prazosin my doctor recently diagnosed me with combat related ptsd which have been causing nightmares. while waiting to see a psychologist she prescribed low dose prazosin and low dose trazodone for the time being. i was researching b

2 doctor answers3 doctors weighed in
Dr. Andrius Baskys
Dr. Andrius Baskysanswered
Geriatric Psychiatry 47 years experience
Several : Several studies and case reports suggest that prazosin can benefit individuals with ptsd in reducing sleep disturbances and nightmares. Daytime prazosin has been reported to reduce distress related to trauma cues. However, as you correctly pointed out, taking trazodone and prozosin together could cause undesirable side effects. Why? Both drugs act on so-called alpha-1 adrenergic receptors causing their blockade. This often results in hypotension or drop in blood pressure, especially when the person rapidly changes his or her body posture. This could result in dizziness and sudden increase in the heart rate. Both drugs could also cause excessive sedation. If you already taking medications for high blood pressure, prazosin and trazodone may potentiate their action, causing undesirably low blood pressure. However, the final decision in recommending both prazosin and trazodone rests with your physician who examined you and knows your medical history. Hope this information helps but please do not hesitate to contact my office if you have further questions.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Heidi Fowler
Psychiatry 26 years experience
Hello. : Hello. Treating combat related ptsd is one my mainstays. I agree with dr basky's. I have found prazosin exceptionally helpful for wounded warriors who have nightmares and disrupted sleep -however, i usually have to work the dose up by the milligram. Trazodone is also very effective but only about half of my patient's can tolerate it due to daytime sedation. I normally with start with one or other.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Dec 16, 2019


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