A member asked:

Does taking ranitidine zantac and marijuana have a side effect yesterday around 1 pm i took a ranitidine and last night around 8:30 i smoked some marijuana and everything was all blurry and i fainted three times

2 doctors weighed in across 2 answers
Dr. Heidi Fowler answered

Specializes in Psychiatry

I : I can not provide a definitive answer to your question. Ranitine binds to cytochrome p-450 in the liver. The active ingredient in marijuana is tetrahydrocannabinol. One of the liver enzymes that helps to metabolise tetrahydrocannabinol is cytochrome p-450. Having said that, I do not know if it the ranitidine effected the rate that cannais you smoked was metabolized. Marijuana can have some very toxic effects. When you stated that everything was "all blurry" I do not know if that was meant litterally or figuratively. Marijuana can cause visual hallucinations and as well as a number of serious psychiatric problems. User beware.

Answered 12/23/2017

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Tagamet/Zantac: This class of drugs is a well known inhibitor of the enzymes used in the liver to break-down or de-toxify many medications/drugs. So your usual thc hit stayed around, and its intensity increased, by your use of ranitidine.

Answered 4/1/2018

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