How quickly does zoloft (sertraline) start to become effective?

4 to 6 weeks: Most antidepressants take several weeks to begin to build up in your system to a therapeutic level.

2-3 weehs: It may b faster but this is the usual answer.

Zoloft (sertraline) onset: According to research studies, about 75% of patients will improve in the first four weeks, but it may take 4 to 6 weeks for the other 25% to improve with antidepressant treatment. Also, it is important a person takes an adequate dose, for some, this may be as much as 150-200 mgs per day. I would go to a dr. Who would see me every few weeks until i was better. Good luck.

It may take four to: Six weeks once you reach an optimum dose. The dose is usually titrated upward from a starting dose of 25 mg per day.