A member asked:

What would be the cause of my 27 yo husband being diagnosed with rhabdomyolysis? we went to the local er because my husband was having trouble with his acid re-flux. while there they had ran a couple of test and found his cpk (?) levels were extremely el

2 doctors weighed in across 2 answers

If : If the er could not uncover the reason why he went into rhabdomyolysis, then you may never know. I will list some common causes for you, maybe this will help: muscle trauma or crush injury burns(severe) physical torture prolonged lying down prolonged coma severe muscle contractions from seizures cocaine use increased body temperature extreme physical activity drug and alcohol intoxication low electrolytes genetic muscle diseases near drowning low body temperature), medications: most commonly statins, which are used to treat high cholesterol; psychiatric medications, anesthesia medications, HIV medications, colchicine(used for gout) viruses and some bacteria untreated hypothyroidism (low thyroid level) myopathies(muscle diorders) snake venom best of luck.

Answered 10/3/2016

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Dr. Stephen Christensen answered

Specializes in Family Medicine

As : As you probably know, there are different types, or isoenzymes, of CPK circulating in your bloodstream. Cpk-mb is primarily found in your heart (it's the isoenzyme that's elevated during a heart attack). Cpk-mm comes mainly from skeletal muscle, and cpk-bb is found chiefly in brain and lung tissue. Differentiating among the various isoenzymes helps focus the search for the cause of an elevated CPK level. Since your husband was told he had rhabdomyolysis, it was apparently his cpk-mm that was high. There are a number of conditions that can lead to elevated cpk-mm levels, including muscular injuries (bruises, contusions, etc.), vigorous exercise, and inflammatory disorders that affect muscle, such as polymyositis or dermatomyositis (see links below). Another condition called "macro-ck" is sometimes associated with certain cancers (e.g. Non-hodgkin's lymphoma) or liver disease, but macro-ck rarely causes your CPK to rise above 2, 000 or so. Clearly, your husband should be evaluated to rule out an occult cause for his elevated cpk. A repeat reading in a week or two would indicate whether this is a persistent problem that demands further investigation or a transient phenomenon related to a muscle injury or exertion. I hope things go well! http://www.Nlm.Nih.Gov/medlineplus/ency/article/000839.Htm http://www.Nlm.Nih.Gov/medlineplus/ency/article/000428.Htm.

Answered 10/4/2016

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