A member asked:

What is an over expression of p53 brain tumor pathology? is this good or bad? grade2 astrocytoma 31 y/o male

4 doctors weighed in across 2 answers
Dr. Kenneth Reichert answered

Specializes in Neurosurgery

P53 Protein Glioma: Malignant glioma is the most common brain tumor in adults. Mutations in the p53 tumor suppressor gene are frequently detected in gliomas. P53 is well-known for its ability to control cell division, especially malignant cells. Exactly how p53 works in order to prevent malignant transformation of cells remains unknown, but the higher the p53 protein, the better your own body can fight tumor growth.

Answered 2/28/2013

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Not clearly bad: Many low grade astrocytomas (grade ii) have p53 gene mutations which lead to overexpression of the protein (more precisely the protein is more stable than normal and isn't degraded. There is no completely clear evidence of a higher risk of progression to high grade, or of other bad outcomes, from the p53 gene status or protein levels.

Answered 9/7/2013

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